Cruelty Free
Cruelty Free
Designed to deliver “treatment-like” results and is known as “microneedling in a bottle”.
Embrace the extraordinary capabilities of the 8-in-1 BioSerum, our multifunctional marvel in anti-aging skincare. Intuitively meeting your skin’s unique needs, DefenAge's iconic bestseller is designed to deliver visible, targeted rejuvenation. As a biologically advanced serum concentrate, it features an unprecedented concentration of defensin molecules from the Age-Repair Defensin® Complex, affirming its position as a superior anti-aging serum. Esteemed by dermatologists as an excellent retinol alternative, the 8-in-1 BioSerum serves as a premier rejuvenation serum, either alone or in combination with retinol or bakuchiol serums. Experience the cumulative benefits of eight distinct serums and unveil your best skin ever with this rejuvenating serum.
Ideal as a solo skincare powerhouse, the 8-in-1 BioSerum is renowned as a "treatment multiplier" and likened to "microneedling in a bottle." Dermatologists recommend this rejuvenation serum for enhancing the results of aesthetic procedures such as microneedling, RF-microneedling, fractional and ablative laser treatments, and Sofwave.
Dive deeper into the unique fusion offered by the 8-in-1 BioSerum. This innovative formula masterfully brings together the benefits of eight specialized serums, delivering a holistic approach to skincare that’s comprehensive and unparalleled:
1. Anti-Oxidants Serum: A robust blend of antioxidants, including Ergothioneine, combats environmental damage while brightening and energizing the skin.
2. Niacinamide Serum: Rich in high-performance Niacinamide (Vitamin B3), it soothes, hydrates, revitalizes the skin’s moisture barrier, and promotes a uniform skin tone.
3. Hyaluronic Acid (HA) Serum: Infused with low-weight Hyaluronic Acid for deep hydration, supplemented by a suite of intense moisturizers.
4. Collagen Serum: Enhanced with beta-defensin 3, the BioSerum boosts collagen, improves elasticity and firmness, and diminishes sagging.
5. Calming Serum: Infused with a fine blend of soothing and calming botanical molecules.
6. Peptide Serum: A bespoke blend of peptides, including Palmitoyl Tripeptide-38, targets critical aging areas, smoothing wrinkles and refining skin texture.
7. DNA-Repair Enzyme Serum: Features enzymes from Mediterranean Arabidopsis, renowned for repairing common DNA damage.
8. Retinol-Alternative Serum: The crowning jewel of the 8-in-1 BioSerum is the highest concentration achievable of Alpha-Defensin 5—DefenAge’s exclusive and revolutionary ingredient. This bio-synthesized molecule marks a triumph in regenerative biology, renowned for its unparalleled ability to activate age-repair pathways, foster new skin development, and serve as a safe, highly effective alternative to retinol. The inclusion of Alpha-Defensin 5 represents not merely an advancement in skincare, but a paradigm shift in our approach to skin rejuvenation and anti-aging. The presence of this potent ingredient in the serum parallels the benefits of traditional retinol serums with a gentler approach, minimizing potential irritation and making it suitable for all skin types.
The 8-in-1 BioSerum transcends traditional skincare, unifying eight essential benefits for a youthful, radiant complexion. It's not just an anti-aging serum; it’s a complete solution for visible skin rejuvenation.
Rejuvenating Smoothness: Enhancing visible skin health and quality.
Reducing Signs of Aging: Minimizing the look of fine lines, wrinkles, pores, and pigmentation.
Promoting Radiance: Reviving skin’s natural moisture for a luminous glow.
Brightening Skin Tone: Improving overall clarity and luminosity.
Renewing the Feeling of Firmness and Elasticity: Restoring texture for a youthful feel.
Calming Redness: Beneficial for sensitive skin, helps improve the appearance of skin redness.
Promoting Skin Barrier and Immunity: Helps to strengthen skin’s natural defenses for optimal health.
Rich in Defensins: Contains five times more defensin molecules than other skincare formulas.
Feather-Light Feel: Offers a lightweight application for a comfortable wear.
Versatile Use: Safe and effective for the entire face, skin around eyes, lips, neck, and décolleté.
Targets Crepey Skin: Excelling on thin skin areas like the neck and arms.
Rapid Anti-Aging Effects: Delivers visible results within a few weeks.
Suitable for All: Ideal for daily use, for both men and women, and for all adult ages, including people above 70.
Gentle for Sensitive Skin: Non-irritating, retinol.
Broad Tolerance: Effective for diverse skin types, including those with rosacea and melasma.
Highly effective for pre- and post-aesthetic procedures: Enhances outcomes of aesthetic treatments like microneedling, fractional and ablative laser therapy. Primes the skin to a quick and robust response. Optimizes healing and minimizes the risk of acne break-outs post-procedure.
Pre-Filler Prime: Ideal for preparing skin before fillers — start using four to six weeks before procedures.
Customer Favorite: Known as DefenAge's most liked product with impressive feedback.
Made in the U.S.A.
Age-Repair Defensins® | 5X | DefenAge's Exclusive
promotes new skin • anti-aging on a global scale • retinol alternative
Defensins are natural molecules. They signal our body to create new skin by activating the dormant reserves of "fresh" and young cells. DefenAge contains an identical copy of human defensins made via bio-synthesis; defensins are exclusive to DefenAge.
Niacinamide
hydration • firmness & elasticity • brightening
Niacinamide soothes, revives the skin’s natural moisture barrier, renews the feel of skin firmness and elasticity, and brightens overall skin tone. The 8-in-1 BioSerum is named 'Best Niacinamide and Hyaluronic Acid Serum of 2024' by Good Housekeeping magazine.
Hyaluronic Acid | Low Molecular Weight
• hydration •
Promotes hydration and improves texture for remarkably smooth and even skin.
Fine Blend of Soothing and Calming Ingredients
• addresses inflamm-aging • skin calming & soothing •
This formula is infused with a powerful and concentrated composition of soothing and calming botanical molecules, including extract from the flowers of ‘love in a puff’, a medical plant known as a cortisone-free alternative, Epigallocatechin Gallatyl Glucoside, a water-soluble form of one of the most active molecules found in green tea, and black currant seed extract.
Fine Blends of Natural Antioxidants, Enzymes and Hydrating Technologies
antioxidants • hydration • soothing
Our “know-how”-protected, advanced and powerful blends of antioxidants and enzymes address environmental cell damage and defend against free radicals. They brighten, clarify and energize the skin for a revitalized radiance and luminosity.
STEP THREE | 8-in-1 BioSerum
Daily: AM | PM
Place 1 pump of 8-in-1 BioSerum onto fingertips. Lightly massage with fingertips first around eyes, then over entire face. Use a second pump on neck and décolleté. Follow with sunscreen.
Suitable for all skin types.
For external use only. Keep out of eyes. If product enters eyes rinse thoroughly with water. Discontinue use and consult a physician if irritation or allergy develops. Keep out of the reach of children.
The 8-in-1 BioSerum is ophthalmologist and dermatologist tested safe for contact lens wearers. Clinically proven effective. The 8-in-1 BioSerum and its key defensin-based ingredient have been tested in 11 clinical studies.
The 8-in-1 BioSerum was tested in a comprehensive, multi-center, double-blind, placebo-controlled dermatology safety and efficacy study as a part of an anti-aging skincare regimen. The study design, raw data, results, and conclusions are published in peer-reviewed Journal of Drugs in Dermatology (Taub, A., MD, Bucay, V. MD, Keller, G., MD Mehregan, D., MD, Williams, J., PhD; 2018, p. 426-441). The data from pilot open-label and following pilot double-blind efficacy studies are on file.
Additional ophthalmology and irritation-safety studies of the 8-in-1 BioSerum were performed by a third-party clinical center.
The concentration range of defensin-molecules infused into Age-Repair Defensin® complex have also been tested in independent clinical safety studies.
All clinical studies were conducted in US-based clinics located in California, Illinois, Texas, and New Jersey in accordance with federal and local regulatory requirements and Good Clinical Practice. The clinical study protocols and study executions were reviewed and monitored by independent Institutional Review Boards.
We are proud to report that all clinical studies returned an outstanding safety and efficacy product profile. Because of the exceptional results seen with the use of the 8-in-1 BioSerum and the unique mechanism of action of Defensin-molecules, the 8-in-1 BioSerum is commonly called "microneedling in a bottle."
Microneedling and RF-Microneedling: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.
Fractional laser: 24-48 hours post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.
Ablative laser: 7 days post-procedure, apply the 8-in-1 BioSerum 2 times a day for 2-4 weeks.
Safewave and other non-invasive procedures: Immediately post-procedure, apply Clinical Power Trio for 2-4 weeks.
The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. In addition, this product does not contain fragrance.
The bottle, box and package components are fully recyclable, please recycle.
We do not test products on animals.
The effectiveness of our 8-in-1 BioSerum in anti-aging and rejuvenation stems from its unique blend of potent ingredients and advanced technology. Central to its formula is the Age-Repair Defensin® Complex, which contains defensin molecules. These bio-synthesized molecules are key to the serum’s effectiveness as they tap into skin's natural regenerative processes. Here's how the serum works to combat aging and visibly rejuvenate your skin: Comprehensive Formulation: Unlike traditional serums, our 8-in-1 BioSerum combines the benefits of eight specialized serums in one. Each 'serum' within targets specific aging concerns, from hydration to collagen boosting, offering a complete anti-aging solution. Advanced Defensin Technology: The serum's high concentration of Alpha-Defensin 5 and Beta-Defensin 3, exclusive to DefenAge, actively help to rejuvenate skin by promoting new, younger-looking skin and enhancing skin's natural barrier. These molecules are recognized as a safe and effective alternative to retinol, making the serum suitable for even sensitive skin types. Multi-Dimensional Benefits: The 8-in-1 BioSerum addresses various visible signs of aging – it smoothens fine lines and wrinkles, improves skin texture, boosts hydration, enhances firmness, and provides potent antioxidant protection. This comprehensive approach ensures visible rejuvenation of the skin. Proven Results: Supported by dermatologists and aesthetic professionals, our serum is not just a product but a scientifically-backed solution. Its efficacy in anti-aging and visible skin rejuvenation has been proven through rigorous clinical studies and real-world use. By integrating these advanced components and science-backed ingredients, the 8-in-1 BioSerum stands out as a highly effective product for both anti-aging and visible skin rejuvenation, delivering noticeable results that are both rapid and long-lasting.
The reason is because of a unique property of defensin molecules. Our bio serum contains DefenAge’s highest dose of defensins, which not only stimulate new skin, but also have shown to be effective in preventing water loss via the skin-surface’s natural “tight junction” mechanism. In other words, defensins “lock gaps” between surface cells; therefore water cannot go out, it is locked inside, but together with this – nothing goes in, meaning that if you apply any other creams or serums on top of the 8-in-1 BioSerum, their ingredients may not be absorbed. We recommend that all skin care products in your routine be layered before the 8-in-1 BioSerum, only makeup and sunscreen should be layered on top in the morning, and nothing should be layered at night; please review the dermatologist recommendations on night skincare routines on our How-To Page.
Please be patient, more is not better. More results will not show up just because of an overuse of the bio serum. Concentrations of ingredients are very well balanced in the formula, please just follow with the recommended dosage and do it regularly: morning and night – results will not disappoint. Use one pump of the 8-in-1 BioSerum on the face and one on the neck. We also recommend exfoliating the skin regularly to see results faster – removing old cells from skin’s surface will unveil beautiful new skin; DefenAge’s gentle solution for exfoliation is the 2-Minute Reveal Masque.
DefenAge’s 8-in-1 BioSerum contains a fine blend of naturally powerful anti-oxidants. We do not restrict DefenAge users from using vitamin C serum, although we believe that it is unnecessary.
This is true. Due to the high concentration of defensin molecules, the skin will become smoother after using 8-in-1 BioSerum, therefore makeup will be applied easier than usual. Some consumers even say, “I do not need foundation after I started using DefenAge's bioserum.”
Yes it is. The 8-in-1 BioSerum is safe for acne prone skin, our bio serum underwent multiple safety studies that returned an outstanding safety profile. Please be sure that you use the exact quantity of the product that we recommended, and do not exceed it: 1 pump of the bio serum for entire face and 1 pump on the neck.
