The complete lip care solution: visibly smooths, plumps, hydrates, and protects for softer, more youthful lips.
Step into the future of lip care with DefenAge’s 12-Factor Revitalizing Lip Enhancer, a breakthrough serum designed to rejuvenate your lips from within. Unlike instant lip plumpers that deliver a short-lived effect, this advanced formula provides long-term benefits powered by DefenAge's exclusive Age-Repair Defensins®.
A True Anti-Aging Lip Treatment – Defensin-Powered Rejuvenation:
Stimulates your body's natural skin renewal process to produce fresh, youthful skin cells, leading to lasting improvements in lip volume and smoothness.
Promotes collagen production for firmer, more voluminous lips over time—without relying on temporary swelling or irritation.
12 Active Factors for Complete Lip Care:
Offers a comprehensive solution, addressing hydration, repair, protection, and volume, unlike typical plumpers that focus solely on enhancing fullness.
Infused with antioxidants to shield lips from environmental damage, while also reducing the appearance of fine lines like “lipstick wrinkles" & "smoker's lines"
Non-Irritating, Gentle Formula; Needle-Free Solution:
Free from harsh irritants commonly found in instant plumpers, which can cause tingling or burning. Instead, it soothes and nourishes lips, delivering hydration and repair without discomfort.
No Needles, Just Results: Unlike invasive injectable treatments, this serum provides all the benefits of lip plumping and anti-aging without the pain or recovery time.
Luxurious Application Experience:
Packaged in an innovative airless bottle with a Zamac® ‘gold’ tip that provides a cooling, soothing effect during application, enhancing the experience without irritation.
Clinically Tested and Dermatologist Approved:
Developed with input from leading dermatologists, this serum is designed to deliver deep hydration, smooth lip contours, and restore softness for lips that feel and look more vibrant over time.
Get ready for lips that are not only soft and radiant, but also naturally fuller and youthful—with results that last!
This unique formula revitalizes the overall health and appearance of your lips:
Boosts lip volume and firmness, creating a plumper, more defined appearance.
Infuses deep moisturization, hydrating away dullness and dryness, while leaving lips luxuriously soft and irresistibly smooth.
Visibly smooths fine lines and "lipstick wrinkles", for a youthful, rejuvenated look.
Supports the natural renewal process, revealing fuller, more vibrant lips that feel as youthful as they look.
Delivers powerful antioxidant defense, shielding lips from environmental stressors and keeping them healthy and radiant.
Alpha-Defensin 5
The crowning jewel of the 12-Factor Revitalizing Lip Enhancer Alpha-Defensin 5 is DefenAge’s exclusive and innovative ingredient, formulated in the highest concentration achievable. This bio-synthesized molecule is celebrated for its ability to support natural age-repair pathways and encourage the development of new, younger-looking cells, making it a highly effective alternative to traditional retinol. Alpha-Defensin 5 advances the science of lip care by promoting a smoother, firmer, and more youthful appearance while remaining gentle and suitable for all skin types. It offers similar benefits to retinol-based serums but with a gentler, non-irritating approach.
Beta-Defensin 3
Supports collagen production, helps improve elasticity and firmness, and strengthens lip surface cells to retain valuable moisture.
Niacinamide (Vitamin B3)
Soothes, hydrates, revitalizes the moisture barrier, and helps promote a uniform tone across the lips.
Panthenol (Vitamin B5)
Helps maintain the integrity of the lip surface barrier, improves elasticity, and provides deep hydration for a smoother, firmer appearance.
A blend of Red Algae Extract and Tara Tree Fruit Extract
Helps reinforce the lips' barrier against environmental stressors, prolongs makeup wear, and provides immediate soothing comfort.
Organic Mustard Sprout Extract
Instantly hydrates and plumps lips, visibly reducing fine lines and enhancing natural lip definition and shape.
Ultra Filling Hyaluronic Acid Fine Spheres
Delivers long-lasting hydration, leaving lips smooth and elastic while reducing the look of fine lines.
Maximized Lip Peptide Complex
Moisturizes, firms, and smooths lips while enhancing definition and contour.
Brown Kelp Extract
Helps improve lip definition, hydration, and overall volume.
Butyrospermum Parkii (Shea) Butter
Boosts moisture, calms and soothes dry, chapped lips, leaving them smooth and supple.
Green-Tea Extract
A powerful antioxidant that helps protect lips from environmental aggressors and nourishes the delicate lip surface.
Extracts of 'Love in a Puff' flower and Black Currant seeds
A soothing, barrier-strengthening botanical complex that helps provide immediate comfort and protect lips from irritants.
Embark on your journey to softer, fuller, and more youthful lips with the 12-Factor Revitalizing Lip Enhancer — where cutting-edge science meets beauty to transform your lip care routine.
1. With the cap on, shake the bottle well before first use.
Take off the cap.
2. Apply once or twice daily. Hold the bottle at the indented areas with 2 fingers. Push down on both sides of the applicator to release a drop of the serum.
3. Use the tip of the applicator to smooth one pump over the lips.
DefenAge and Age-Repair Defensins® have been tested in more than 30 clinical studies, demonstrating the safety and efficacy of Defensin technology and DefenAge. The 12-Factor Revitalizing Lip Enhancer has also been evaluated by Board-Certified dermatologists and proven to deliver effective results.
The cleanliness of our products is DefenAge’s philosophy. We do not use “convenient” ingredients that have compromised safety, and before we add any component into our formulas, we perform comprehensive research around it. To review the full list of ingredients that are excluded from DefenAge, please go to our Clean Beauty page. In addition, this product does not contain fragrance.
We do not test products on animals.
The 12-Factor Revitalizing Lip Enhancer is a lip serum powered by Age-Repair Defensins, designed to support your lips' natural renewal process. Over time it helps build volume and firmness, smooths the look of fine lines, and delivers deep hydration for softer, more youthful lips.
The 12-Factor Revitalizing Lip Enhancer is a skincare serum for the lips, formulated to fit into your daily routine morning and evening. Powered by Age-Repair Defensins, it works over time to build volume, smooth lines, and deliver deep hydration, the same way a facial serum supports skin renewal.
A gentle shake before the first use gets the formula ready, and from there it's simple: a light press on both sides of the applicator releases a single drop, smoothed over the lips with the tip. Once or twice a day, morning and evening, fits it right into the rest of the routine.
Unlike an instant plumper, the 12-Factor Revitalizing Lip Enhancer works with the lips' natural renewal process, so results build gradually with continued use rather than showing up all at once. Hydration and softness are often noticeable right away, while volume and smoothness continue to improve the longer it's part of the routine.
Lipstick and lip gloss both apply beautifully right over the 12-Factor Revitalizing Lip Enhancer. A few moments for the serum to absorb sets the stage, then lip color goes on as usual, with lips left prepped and nourished underneath.
Shea butter, panthenol, and hyaluronic acid work together in the 12-Factor Revitalizing Lip Enhancer to soothe dryness and deliver deep, lasting hydration, making it a good fit for lips that feel dry or chapped. For lips that are cracked, bleeding, or not healing, a dermatologist is worth checking with first.
