Why do dermatologists and skincare professionals recommend medical-grade skincare brands?

Medical-grade skincare brands are formulated with higher concentrations of active ingredients and are often supported by clinical research. These products are designed to target concerns like aging, discoloration, and texture more effectively than traditional over-the-counter skincare. At DermSilk, we focus on dermatologist-recommended brands that prioritize science-backed formulations and real results.

How do I choose the right professional skincare brand for my skin concerns?

The best professional skincare brand depends on your goals. Some brands specialize in anti-aging and collagen support, while others focus on hydration, pigmentation, or skin barrier repair. Look for products that match your primary concern and skin type, and consider starting with core essentials like a cleanser, treatment serum, and daily moisturizer. DermSilk offers a curated selection of clinically trusted brands so you can build a routine with confidence.

How can I tell if premium skincare products are authentic when shopping online?

Authentic professional skincare should always be purchased through authorized retailers. Buying from trusted providers helps ensure products are fresh, properly stored, and sourced directly from the brand. DermSilk partners directly with authorized manufacturers to provide genuine, professionally recommended skincare products so customers can shop with confidence.

What brands does DermSilk.com carry?

Plated Skin Science, Obagi, SkinMedica, iS Clinical, Sente, EltaMD, PCA Skin, Pavise, Hydrinity, Epicutis, Nutrafol, Epicuren Discovery, Allies of Skin, Augustinus Bader, IMAGE Skincare, ISDIN, Neocutis, Marini SkinSolutions (Formerly known as Jan Marini), Murad, NeoGenesis, Omnilux, Revision Skincare, SK-II, SkinBetter Science and ZO Skin Health.

DefenAge 24/7 Barrier Balance Cream (1.5 oz)

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DefenAge 24/7 Barrier Balance Cream (1.5 oz)

$106.00

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Free ($19 Value) DefenAge 24-Hour Fast Starter Kit *

Receive a Free ($19 Value) DefenAge 24-Hour Fast Starter Kit * when you spend $299 or more on DefenAge products. Complimentary gift will be awarded at the cart. Offer valid limited time only, while supplies last.

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Is DermSilk an authorized retailer of DefenAge?

Yes. DermSilk is an authorized retailer for DefenAge and every brand we carry.

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You can reach us at info@dermsilk.com or (866) 405-6608 during business hours. See our contact page for full details.

Where can I find the return policy?

Our full return policy is on the refund policy page in the site footer.

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Cruelty Free

This product is covered by U.S. Patent No. 11,491,096.

An intensely hydrating cream infused with our exclusive Age-Repair Defensins® technology, this formula combines multi-action barrier-balancing ingredients and skin-brightening actives to deliver visible rejuvenation. Together, these powerhouse components support the skin’s natural renewal process, helping to restore radiance, improve tone and texture, and promote a healthier, more resilient complexion.

WHY OUR 24/7 BARRIER BALANCE ANTI-AGING CREAM IS DIFFERENT

Contains Age-Repair Defensins® to provide exceptional results, strengthens the skin's barrier properties, and lock moisture in the skin by "closing" gaps between skin cells.

Helps repair skin barriers in days, not weeks.

Corrects visible signs of surface aging cell by cell.

Enhances absorption of 8-in-1 BioSerum when applied beforehand.

Made in the U.S.A.

CLEAN BEAUTY

The same as all other DefenAge products, the 24/7 Barrier Balance Cream is formulated with clean skincare in mind. To learn more about DefenAge’s clean standards please visit our Clean Beauty page.

GREEN PLANET

The bottle and box are fully recyclable, please recycle.

Not tested on animals.

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