A.G.E. Interrupter Advanced is a potent wrinkle cream that helps reverse visible signs of aging, including fine lines and deep wrinkles, caused by collagen decline and glycation.
Backed by more than 15 years of glycation research and expertise, A.G.E. Interrupter Advanced is a potent anti-wrinkle cream that helps correct and defend against visible signs of aging. Formulated with 18% concentrated ProxylaneTM, 4.25% wild fruit flavonoids and 0.1% glycyrrhetinic acid, this breakthrough anti-aging moisturizer is clinically proven to help reverse skin-aging glycation by up to 33%. A.G.E Interrupter Advanced contains a high performance formula that is clinically shown to smooth visible lines and deep wrinkles in five facial zones, reduce visible discoloration, and restore skin density. Physician tested to complement RF microneedling treatments for 3x better lifting results in 12 weeks. Physician-tested with GLP-1 patients, A.G.E. Interrupter Advanced, paired with A.G.E. Interrupter Ultra Serum and lifting ultrasound treaments reduce skin laxity -20% vs control in 12 weeks.
THE SCIENCE
What is Skin Glycation?
Glycation is natural process that accelerates visible signs of aging. During the glycation process, excess sugars bind to skin-supporting proteins (like collagen and elastin) and form advanced glycation end-products (A.G.E.s). A.G.E.s weaken collagen, leading to wrinkles and laxity.
Signs of Glycation
Wrinkling and crepiness
Loss of firmness
Dull, sallow complexion
Glycation Dos and Don’ts
A.G.E. Interrupter Advanced + RF Microneedling Treatments
A.G.E. Routine for GLP-1 Users
PHYSICIAN INSIGHT
"A.G.E Interrupter Advanced is a breakthrough in anti-aging skincare because it addresses the complete glycation process, a natural and unavoidable factor of aging that affects all of our skin. I recommend to all my patients looking for at-home skincare to help reverse visible aging and am excited to pair with skin-tightening treatments like radiofrequency microneedling.”
Dr. Sherry Ingraham — Board Certified Dermatologist — Advanced Dermatology
- Visibly corrects a range of wrinkle types including fine lines, deep wrinkles and location-specific creases
- Helps restore skin’s density, which is known to decline as glycation degrades skin’s collagen
- Visibly reduces discoloration for a healthier looking complexion
- Complements collagen remodeling procedure RF microneedling for 3x better lifting results
- Helps reverse collagen glycation, a process known to visibly age skin, by 33%
- Delivers rich all-day hydration, with a luxurious, satin finish
- Free of parabens, drying alcohol, and dyes
18% Concentrated Proxylane — Helps support skin’s integrity and correct visible signs of aging, like wrinkles and laxity.
4.25% Wild Fruit Flavonoids — Combination of blueberry and pomegranate extracts help reduce oxidative stresCB3:CD3s, which can be linked to A.G.E. formation, and protect against free radical damage.
1% Glycyrrhetinic Acid — Helps counter dull tone, which can be linked to A.G.E. accumulation, and is known for its soothing properties.
3% Hepes — Activates natural enzymes in skin to promote even cell turnover while hydrating skin.
1% Niacinamide — Water-soluble vitamin, also known as vitamin B3, soothes and helps support skin’s moisture barrier.
Prep + Dispense
Twice daily, massage a thin, even layer of A.G.E. Interrupter Advanced wrinkle cream onto the entire face, neck, and chest.
Apply + Complete
If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.
After 12 weeks, A.G.E. Interrupter Advanced improved attributes associated with skin aging and glycation, including lines and deep wrinkles in five facial zones.
14% Reduction in global fine lines
11.5% Reduction in forehead wrinkles
11% Reduction in nasolabial folds
7% Reduction in marionette wrinkles
7% Reduction in glabellar wrinkles
7% crow's feet lines
HOW DOES A.G.E. INTERRUPTER ADVANCED DIFFER FROM THE ORIGINAL A.G.E. INTERRUPTER?
Similar to its predecessor, A.G.E. Interrupter Advanced is an anti-wrinkle cream formulated to target the visible effects of glycation on the skin. Backed by more than 15 years of glycation research and expertise, this next-generation technology now addresses all phases of the glycation process, including UV-induced glycation, helping to correct existing signs of skin aging and defend against new and reoccurring damage. This anti-aging cream is now formulated with an increased concentration of ProxylaneTM (20% higher activity than A.G.E. Interrupter) and wild fruit flavonoids (12.5% higher activity than A.G.E. Interrupter), as well as new glycyrrhetinic acid, A.G.E. Interrupter Advanced is clinically proven to smooth the appearance of fine lines and wrinkles in five facial zones targeted for aesthetic procedures.
AT WHAT AGE SHOULD YOU USE ANTI-WRINKLE CREAMS?
It’s generally recommended to start using anti-wrinkle creams in your mid-to-late 20’s as this is when the dermis layer starts producing less collagen. Even before then, you should begin building a skincare routine to help prevent skin damage.
WHY DOES A.G.E. INTERRUPTER ADVANCED HAVE A DIFFERENT COLOR THAN THE PREVIOUS FORMULA?
A.G.E. Interrupter Advanced features a synergistic blend of wild fruit flavonoids (blueberry and pomegranate extracts) that deliver 12.5% higher activity than the single flavonoid (blueberry extract) used in the original A.G.E. Interrupter formulation. Together, these naturally derived ingredients can contribute to a slightly pink hue; while this color may vary, the effectiveness of the formula remains constant.
WHAT IS THE DIFFERENCE BETWEEN A.G.E. INTERRUPTER ADVANCED AND TRIPLE LIPID RESTORE 2:4:2?
A.G.E. Interrupter Advanced and Triple Lipid Restore 2:4:2 are complementary corrective creams that offer unique anti-aging benefits.
A.G.E. Interrupter Advanced helps reduce fine lines, wrinkles, and visible discoloration by helping reverse the natural glycation process known to accelerate visible aging. This anti-wrinkle face cream is formulated with a whipped, creamy-balm texture, this potent product may be used alone or in conjunction with other corrective treatments and moisturizers.
Triple Lipid Restore 2:4:2 helps address the loss of facial fullness, rough skin texture, and dullness by helping refill essential skin lipids and restore the skin’s moisture barrier. Its silky, ultra-rich texture provides an intensely nourishing layer to lock in key ingredients from your skincare formulas.
WHAT DOES A.G.E. INTERRUPTER ADVANCED DO?
A.G.E. Interrupter Advanced is an advanced anti-wrinkle cream that helps reverse visible signs of aging caused by collagen decline and advanced glycation end-products (A.G.E.), a major factor of the natural aging process. The fine-line cream counters these factors by improving the skin’s integrity, reducing oxidative stress, promoting cellular turnover, and improving hydration.
CAN I USE A.G.E. INTERRUPTER ADVANCED WITH RETINOL?
Yes, if using with a retinol at night, apply A.G.E. Interrupter Advanced anti-wrinkle cream after retinol application.
DOES A.G.E. INTERRUPTER ADVANCED CREAM GET RID OF WRINKLES?
Yes, A.G.E. Interrupter Advanced is a face and neck wrinkle cream that visibly reduces the appearance of five types of wrinkles, including forehead wrinkles, nasolabial folds, marionette wrinkles, glabellar wrinkles, and crow’s feet.
WHAT IS GLYCATION?
Glycation, a major factor of intrinsic and extrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.). Glycated collagen and elastin fibers lose the ability to function normally and cannot be broken down, repaired, or replaced, which ultimately leads to severe wrinkling of the skin. Applying an anti-glycation cream, like A.G.E. Interrupter Advanced, can counter the effects glycation has on the skin with a synergistic blend of key ingredients that promote cellular turnover, reduce oxidative stress, and improve hydration.
HOW DOES A.G.E. INTERRUPTER ADVANCED WORK?
A.G.E. Interrupter Advanced works to improve the appearance of fine lines and deep wrinkles by countering the effects of skin glycation. This is done through a unique blend of ingredients that work together to promote cell turnover, reduce oxidative stress, and hydrate skin.
HOW LONG DOES A.G.E. INTERRUPTER ADVANCED TAKE TO WORK?
While the timeline can vary, participants in one study saw improvements to the appearance of lines and deep wrinkles in just 12 weeks.
